Curcumin
Super Bio-Curcumin
400 mg, 60 vegetarian capsules
Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties. Curcumin is also found to increase detoxifying enzymes and promote healthy DNA function.
Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body.
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.
Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body. Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).
Other clinical trials suggest roles for curcumin in helping maintain healthy lipid profile, bowel, and joint functions. Curcumin can also help maintain normal healthy platelet function, and have immunomodulatory effects by inhibiting histamine release from mast cells. Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.
Curcumin may effectively support pancreatic islet health. Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals, protecting against damaging free radicals, and promoting normal cell cycle growth.
The problem is that curcumin is poorly absorbed into the bloodstream. Super Bio-Curcumin® absorbs up to seven times better than conventional curcumin. So this patented formula represents the most cost-effective way to supplement with this critical nutrient. Studies show that one 400 mg capsule a day of this turmeric compound can provide curcumin blood levels equal to ingesting 2,500–2,800 mg of commercial curcumin supplements. And not only does this turmeric formulation provide far greater peak blood levels, but the curcumin remains in the bloodstream almost twice as long as conventional supplements. And this enhanced absorption delivery complex provides other beneficial turmeric compounds in addition to standardized curcumin.
ABSTRACT
Curcumin has been widely used as a spice and coloring agent in foods. Recently, Curcumin was found to possess chemopreventive effects against skin cancer, forestomach cancer, colon cancer and oral cancer in mice. Clinical trials of curcumin for prevention of human cancers are currently ongoing. In this study, we examine the chemopreventive effect of curcumin on murine hepatocarcinogenesis. C3H/HeN mice were injected i.p. with N-diethylnitrosamine (DEN) at the age of 5 weeks. The curcumin group started eating 0.2% of curcumin-containing diet 4 days before DEN injection until death. The mice were then serially killed at the scheduled times to examine the development of hepatocellular carcinoma (HCC) and changes in intermediate biological markers. At the age of 42 weeks, the curcumin group, as compared with the control group (DEN alone), had an 81% reduction in multiplicity (0.5 versus 2.57) and a 62% reduction in incidence (38 versus 100%) of development of HCC. A series of intermediate biological markers were examined by western blot. While hepatic tissues obtained from the DEN-treated mice showed a remarkable increase in the levels of p21(ras), PCNA and CDC2 proteins, eating a curcumin-containing diet reversed the levels to normal values. These results indicate that curcumin effectively inhibits DEN-induced hepatocarcinogenesis in the mouse. The underlying mechanisms of the phenomenon and the feasibility of using curcumin in the chemoprevention of human HCC should be further explored.
Each 400 mg capsule of Super Bio-Curcumin® is equivalent to 2,772 mg of a typical 95% curcumin extract.
Watch This Informative Video on the Properties of Super Bio-Curcumin
Supplement Facts
Serving Size 1 vegetarian capsule
Servings Per Container 60
Amount Per Serving
BCM-95® Bio-Curcumin® (Curcuma longa) 25:1 extract (root) [std. to 95% Total Curcuminoids Complex with Essential Oils of Turmeric Rhizome by HPLC (380 mg)]
400 mg
Other ingredients: rice flour, vegetable cellulose (capsule), vegetable stearate, silica.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule daily with food, or as recommended by a healthcare practitioner.
Caution
Do not take if you have gallbladder problems or gallstones. If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.
Note: These statements have not been evaluated by the FDA.
The product is not intended to diagnose, treat, cure, or prevent any disease.
